![]() Many stroke centers have been using tenecteplase in routine clinical practice over the last 3 years, so we wanted to find out if tenecteplase is at least as safe and effective as alteplase outside the controlled environment of clinical trials.” “But the latest guidance from the American Heart Association, based on published clinical trials of tenecteplase for stroke, suggests physicians may consider the drug for ischemic stroke. “Right now, tenecteplase is FDA-approved to treat heart attacks,” said Warach, who is also Stroke Director for Ascension Texas and Chair of Ascension’s national Stroke Affinity Group. Warach’s study examined a data registry of tenecteplase use at hospitals in the U.S., Australia and New Zealand and included three years of data through June 2021. Both tenecteplase and alteplase are federally-approved for use in dissolving clots in blocked heart arteries, but the newer drug is already being used by clinicians to treat ischemic strokes. ![]() Researchers compared its performance with the standard drug for stroke, alteplase, which is injected over 60 minutes. Tenecteplase is a newer generation medication administered by a single five-second intravenous injection. This can result in a corresponding loss of neurologic function. The vast majority of those strokes (87%) are ischemic strokes, which occur when a vessel supplying blood to the brain is obstructed. Nearly 800,000 people in the United States have a stroke every year. Warach will deliver his findings at the American Stroke Association’s International Stroke Conference next week in New Orleans. Warach, M.D., Ph.D., professor of neurology at Dell Medical School at The University of Texas at Austin. A newer generation clot-busting medication called tenecteplase may dramatically reduce the risk of serious complications from bleeding into the brain after stroke treatment, according to preliminary research by Steven J.
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